HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2Z)-3-Amino-2-butenenitrile → HCID 135844978, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2Z)-3-Amino-2-butenenitrile | HCID 5325263 | — |
| Reactant | 1-(4-Methyl-1,3-thiazol-2-yl)propan-2-one | HCID 17930988 | — |
| Reactant | HCID 59492344 | HCID 59492344 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 135844978 | HCID 135844978 | — |
Reaction Steps
150 mg (0.876 mmol) of the compound from example 23A, 135 mg (0.876 mmol) of the compound from example 4A and 71 mg (0.876 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, and the crude product is purified by preparative HPLC (eluent: acetonitrile/water with 0.1% formic acid, gradient 20:80→95:5). 145 mg (44% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404723B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0e7247e88eba41f689a5da3735ec1987 |
| Source note | uspto-grants-2013_03 |