(2Z)-3-Amino-2-butenenitrile → HCID 67018067, compound

Participants

Reaction Steps

47.6 mg (0.295 mmol) of the compound from example 3A, 50 mg (0.295 mmol) of the compound from example 24A and 24 mg (0.295 mmol) of 3-aminocrotononitrile are dissolved in 2 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, and the crude product is purified by preparative HPLC (eluent: acetonitrile/water with 0.1% formic acid, gradient 20:80→95:5). 23 mg (19% of theory) of the title compound are obtained in 90% purity (by LC-MS) and can be further purified by crystallization from ethyl acetate. 3 mg (3% of theory) of the target compound are thus isolated in pure form.

Provenance & Evidence