HCID 57465370, compound → HCID 57465371, compound

Participants

Reaction Steps

to a solution of 2-(4-nitrophenyl)-4-phenyl-5-(trifluoromethyl)oxazole (437 mg, 1307 μmol) in 20 mL acetic acid at room temperature was added zinc dust (1282 mg, 19611 μmol) all at once. An exotherm resulted. The mixture was stirred at room temperature for 2 hours then filtered. The filtrate was concentrated under reduced pressure, taken up in 25 mL toluene and concentrated under reduced pressure again to afford a yellow, foamy solid (350 mg, 88%). ESI+ m/z=305.0 [MH]+.

Provenance & Evidence