Ethyl bromoacetate → HCID 52911641, compound

Participants

Reaction Conditions

Reaction Steps

The obtained 3-[4-Isopropyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]-1-(4-methylaminophenyl)propan-1-one (40 mg, 0.0931 mmol) and diisopropylethylamine (80 μL, 0.462 mmol) were dissolved in anhydrous dimethylformamide (2 mL). Ethyl bromoacetate (66 mg, 0.393 mmol) was added to the solution. The mixture was stirred at 110° C. for 16 hours. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried with anhydrous sodium sulfate to remove the solvent. The obtained residue was purified by silica gel column chromatography with hexane/chloroform (7:3, v/v) to give the desired compound (56 mg) as yellow crystalline product (yield 47%).

Provenance & Evidence