2-Methylbenzhydrol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester phenyl-o-tolyl-methyl ester

HRID 1951618Notes

Reaction equation

HRID 1951618 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[C:17]1([CH:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])[OH:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH:23]([O:24][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 956592-MethylbenzhydrolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 86638968Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester phenyl-o-tolyl-methyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with phenyl-o-tolyl-methanol.

Sources & evidence

ORD record
ord-20e8d1a6321e4c9b85d9fd2e60f40f70
Source dataset
uspto-grants-2013_03
Patent number
US08404712B2

Reaction notes

Loading…