2-Azido-3-(4-bromo-5-methyl-thiophen-2-yl)-acrylic acid methyl ester → methyl 3-bromo-2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

Participants

Reaction Steps

To a refluxing xylene (100 ml) was added the crude product of Step 2 (18 g) in 250 ml of xylene over a period of 20 min. After refluxing for 10 min, the reaction mixture was cooled and concentrated to volume of about 100 ml. The solid was collected by filtration to give 12.5 g of the title compound as a white solid.

Provenance & Evidence