HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Bromo-4-(4-trifluoromethyl-benzyl)-4H-thieno[3,2-b]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Bromo-4-(4-trifluoromethyl-benzyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid | HCID 58297698 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Quinoline | HCID 7047 | — |
| Product | 3-Bromo-4-(4-trifluoromethyl-benzyl)-4H-thieno[3,2-b]pyrrole | HCID 58297672 | 82.3% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of 3 g of the product of Step 4 and 0.3 g of copper powder in 50 ml of quinoline was heated in oil bath at 140° C. for 4 h. The reaction mixture was cooled and acidified with 6 N HCl and then extracted with 150 ml of ether. The ether layer was washed with 200 ml of 2 N HCl, dried over Na2SO4, filtered, and concentrated to give 2.2 g of the title compound as a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404736B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b65f395fb4f64c30bd70efb3bc786c11 |
| Source note | uspto-grants-2013_03 |