HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1951732Generated: November 2, 2026
3-Amino-1-propanol → HCID 86597711, compound
https://huagongshe.com/reaction/1951732
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide | HCID 23502784 | — |
| Product | HCID 86597711 | HCID 86597711 | 87.5% |
Reaction Steps
A mixture of 2.0 g (3.8 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide and 5.6 g (75 mmol) 3-amino-1-propanol was heated at 180° C. under microwave irradiation for 40 min. Dilution with water was followed by extraction with three portions of tert-butyl methyl ether. The combined organic extracts were dried over sodium sulfate and concentrated in vacuo. Flash chromatography gave 1.9 g (87%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08404708B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-fb26cda0e7bf4ae0a9b0a4d1d9e505b0 |
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| Source note | uspto-grants-2013_03 |
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