HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 70497189, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 5-fluoro-1,3-dihydro-2H-indol-2-one | HCID 3731012 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70497189 | HCID 70497189 | — |
Reaction Steps
DMF-DMA (3.15 g, 26.4 mmol) was added into a solution of 5-fluoroindolin-2-one LXXXVIII (2.0 g, 13.2 mmol) in dry THF. The reaction mixture was stirred at rt for 4 hr before being poured into water and extracted by EtOAc. The organic layer was separated and dried by Na2SO4, and concentrated to give (E)-3-((dimethylamino)methylene)-5-fluoroindolin-2-one LXXXVIX.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404738B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b704f7a0e80c49129c6b62c1cb836ddc |
| Source note | uspto-grants-2013_03 |