Hydrochloric Acid → HCID 69042283, compound

Participants

Reaction Steps

[8-(4-Methoxy-butyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine (C-3) (6.44 g, 23.7 mmol) was dissolved in water (9.3 ml); conc. HCl (14.6 ml) was added, and the mixture was stirred for 4 d at room temperature. The reaction mixture was washed with ether (2×50 ml). Then the solution was rendered alkaline with 5N NaOH and extracted with dichloromethane (3×50 ml). The combined organic phases were washed with water (50 ml), dried over Na2SO4 and filtered, and the solvent was removed in vacuo.

Provenance & Evidence