HCID 68697439, compound → HCID 68693412, compound

Participants

Reaction Steps

5% sulfuric acid (600 ml) was added at room temperature to (8-cyclopentylmethyl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethyl-amine (13.4 g, 50 mmol), and the mixture was stirred for 3 d at RT. The reaction mixture was extracted with ether (2×50 ml). Then the aqueous phase was rendered alkaline with 5N NaOH, while cooling with an ice bath, and extraction with dichloromethane (3×50 ml) was carried out. The organic phase was dried over Na2SO4 and concentrated to dryness in vacuo.

Provenance & Evidence