5-Fluoro-2-nitrotoluene → HCID 68582832, compound

HRID 1951778Notes

Reaction equation

HRID 1951778 reaction equation
[Br:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[NH:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:11]=2)=[CH:4][CH:3]=1.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([CH3:29])[CH:28]=1>>[Br:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[N:8]([C:23]3[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([CH3:29])[CH:28]=3)[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 949565-Fluoro-2-nitrotolueneHCID 178477957HCID 178477957, compound

Product 1

HCID 68582832HCID 68582832, compound

Procedure

2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-1H-imidazole (382 mg, 1 mmol) was treated as described in general procedure B using 5-fluoro-2-nitrotoluene (310 mg, 2 mmol) to give 2-(4-bromo-benzyl)-4-(2,4-dichloro-phenyl)-1-(3-methyl-4-nitro-phenyl)-1H-imidazole.

Sources & evidence

ORD record
ord-04991af4d6f24ebf83aa4f298f7783b1
Source dataset
uspto-grants-2013_03
Patent number
US08404731B2

Reaction notes

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