4-tert-Butylphenylboronic acid → HCID 178440746, compound

HRID 1951810Notes

Reaction equation

HRID 1951810 reaction equation
Br[C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[NH:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:11]=2)=[CH:4][CH:3]=1.[C:22]([C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>>[C:22]([C:26]1[CH:31]=[CH:30][C:29]([C:2]2[CH:21]=[CH:20][C:5]([CH2:6][C:7]3[NH:8][CH:9]=[C:10]([C:12]4[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=4[Cl:19])[N:11]=3)=[CH:4][CH:3]=2)=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 178477957HCID 178477957, compound

Product 1

HCID 178440746HCID 178440746, compound

Procedure

2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-1H-imidazole (3.8 g, 10 mmol) was treated as described in general procedure G using 4-tert-butylphenylboronic acid (3.6 g, 20 mmol) to give 2-(4′-tert-butyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1H-imidazole, which was treated as described in general procedure R using 1,4-diiodobenzene (13.2 g, 40 mmol) to give 2-(4′-tert-butyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-1-(4-iodo-phenyl)-1H-imidazole.

Sources & evidence

ORD record
ord-afc190ac2ba44281a585fbfe8862cd75
Source dataset
uspto-grants-2013_03
Patent number
US08404731B2

Reaction notes

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