HRID1951837

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4589189

4-cyclohexylphenylboronic acid

C12H17BO2

反应SMILES：COC(=O)CNc1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(Br)cc2)cc1

HCID68583535

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)CNc1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3ccc(C4CCCCC4)cc3)cc2)cc1

HCID68582815

未命名化合物

PROCEDURE

实验过程

{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (1.5 g, 2.7 mmol) was coupled with 4-cyclohexyl phenyl-boronic acid (700 m g, 3.4 mmol) according to general procedure G to give {4-[2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}acetic acid methyl ester.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-ff5c8809753f46fe893a3956dcb62a2c
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08404731B2
来源说明: uspto-grants-2013_03

反应SMILES

[CH3:1][O:2][C:3](=[O:33])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=3[Cl:24])[N:14]=[C:13]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=2)=[CH:8][CH:7]=1.[CH:34]1([C:40]2[CH:45]=[CH:44][C:43](B(O)O)=[CH:42][CH:41]=2)[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH3:1][O:2][C:3](=[O:33])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=3[Cl:24])[N:14]=[C:13]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:37]3[CH:36]=[CH:35][C:34]([CH:40]4[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]4)=[CH:39][CH:38]=3)=[CH:28][CH:27]=2)=[CH:8][CH:7]=1