4-Cyclohexylbenzeneboronic acid → HCID 68583029, compound

HRID 1951845Notes

Reaction equation

HRID 1951845 reaction equation
[CH3:1][O:2][C:3](=[O:35])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[N:14]=[C:13]2[CH2:27][C:28]2[CH:33]=[CH:32][C:31](Br)=[CH:30][CH:29]=2)=[CH:8][CH:7]=1.[CH:36]1([C:42]2[CH:47]=[CH:46][C:45](B(O)O)=[CH:44][CH:43]=2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[CH3:1][O:2][C:3](=[O:35])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[N:14]=[C:13]2[CH2:27][C:28]2[CH:33]=[CH:32][C:31]([C:39]3[CH:38]=[CH:37][C:36]([CH:42]4[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]4)=[CH:41][CH:40]=3)=[CH:30][CH:29]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 45891894-Cyclohexylbenzeneboronic acidHCID 68582705HCID 68582705, compound

Product 1

HCID 68583029HCID 68583029, compound

Procedure

{-4-[2-(4-Bromo-benzyl)-4-(4-trifluoromethyl-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (1.3 g, 2.4 m mol) was coupled with 4-cyclohexyl-phenylboronic acid (615 mg, 3.0 mmol) according to general procedure G to give {4-[2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(4-trifluoromethyl-phenyl)-imidazol-1-yl]phenylamino}-acetic acid methyl ester.

Sources & evidence

ORD record
ord-4bf42086723a4063bbddf4cb44930e0a
Source dataset
uspto-grants-2013_03
Patent number
US08404731B2

Reaction notes

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