Butanal → HCID 59305475, compound

HRID 1951850Notes

Reaction equation

HRID 1951850 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:19]3[N:20]([C:32]4[CH:37]=[CH:36][C:35]([N:38]5[S:42](=[O:44])(=[O:43])[NH:41][C:40](=[O:45])[CH2:39]5)=[CH:34][CH:33]=4)[CH:21]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=4[Cl:31])[N:23]=3)=[CH:14][CH:13]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]([CH3:11])[CH3:10].[CH:46](=O)[CH2:47][CH2:48][CH3:49]>>[CH2:46]([NH:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:13]=[CH:14][C:15]([CH2:18][C:19]3[N:20]([C:32]4[CH:37]=[CH:36][C:35]([N:38]5[S:42](=[O:44])(=[O:43])[NH:41][C:40](=[O:45])[CH2:39]5)=[CH:34][CH:33]=4)[CH:21]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=4[Cl:31])[N:23]=3)=[CH:16][CH:17]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]([CH3:10])[CH3:11])[CH2:47][CH2:48][CH3:49]

Participants

3

Reactant 2

HCID 261ButanalHCID 59305459HCID 59305459, compound

Product 1

HCID 59305475HCID 59305475, compound

Procedure

5-{-4-[2-(3′-Amino-4′-isobutyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-[1,2,5]thiadiazolidin-3-one-1,1-dioxide (22 mg, 0.03 mmol) was reacted with butyraldehyde (2.2 mg, 0.03 mmol) according to general procedure X to give 5-{4-[2-(3′-butylamino-4′-isobutyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-a95b66acfca3403981f75142ff99329a
Source dataset
uspto-grants-2013_03
Patent number
US08404731B2

Reaction notes

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