4-Butylphenylboronic acid → HCID 68583018, compound

HRID 1951852Notes

Reaction equation

HRID 1951852 reaction equation
[CH3:1][O:2][C:3](=[O:33])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=3[Cl:24])[N:14]=[C:13]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=2)[CH:7]=1.[CH2:34]([C:38]1[CH:43]=[CH:42][C:41](B(O)O)=[CH:40][CH:39]=1)[CH2:35][CH2:36][CH3:37]>>[CH3:1][O:2][C:3](=[O:33])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=3[Cl:24])[N:14]=[C:13]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:41]3[CH:42]=[CH:43][C:38]([CH2:34][CH2:35][CH2:36][CH3:37])=[CH:39][CH:40]=3)=[CH:28][CH:27]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 41008604-Butylphenylboronic acidHCID 68583892HCID 68583892, compound

Product 1

HCID 68583018HCID 68583018, compound

Procedure

{3-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (55 mg, 0.1 mmol) was coupled with 4-n-butyl-phenylboronic acid (36 mg, 0.2 mmol) according to general procedure G to give {3-[2-(4′-butyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester.

Sources & evidence

ORD record
ord-0f817e9fc4bf40689ad95917b36a2cab
Source dataset
uspto-grants-2013_03
Patent number
US08404731B2

Reaction notes

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