HCID 43145308, compound → HCID 59305533, compound
Reaction equation
Br[C:2]1[CH:39]=[CH:38][C:5]([CH2:6][C:7]2[N:8]([C:20]3[CH:21]=[C:22]([C:26]4[S:30](=[O:32])(=[O:31])[N:29]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:28](=[O:37])[CH:27]=4)[CH:23]=[CH:24][CH:25]=3)[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:11]=2)=[CH:4][CH:3]=1.[CH:40]1([CH2:46][O:47][C:48]2[CH:53]=[CH:52][C:51](B(O)O)=[CH:50][CH:49]=2)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[C:33]([N:29]1[C:28](=[O:37])[CH:27]=[C:26]([C:22]2[CH:23]=[CH:24][CH:25]=[C:20]([N:8]3[CH:9]=[C:10]([C:12]4[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=4[Cl:19])[N:11]=[C:7]3[CH2:6][C:5]3[CH:4]=[CH:3][C:2]([C:51]4[CH:52]=[CH:53][C:48]([O:47][CH2:46][CH:40]5[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]5)=[CH:49][CH:50]=4)=[CH:39][CH:38]=3)[CH:21]=2)[S:30]1(=[O:32])=[O:31])([CH3:35])([CH3:36])[CH3:34]Participants
3
Procedure
5-{3-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-2-tert-butyl-isothiazol-3-one-1,1-dioxide (7 mg, 0.01 mmol) was treated as described in general procedure G using 4-(cyclohexylmethoxy)-phenylboronic acid (5 mg, 0.02 mmol, prepared according to general procedure H) to give 2-tert-Butyl-5-{3-[2-(4′-cyclohexylmethoxy-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-isothiazol-3-one-1,1-dioxide.
Sources & evidence
- ORD record
- ord-eedd469904834a14a0ceb24a644f50a0
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08404731B2
Reaction notes
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