HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyclohexylvinyl boronic acid → {4-[2-[4-(2-Cyclohexyl-vinyl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyclohexylvinyl boronic acid | HCID 4185149 | — |
| Reactant | {4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester | HCID 68583535 | — |
| Product | {4-[2-[4-(2-Cyclohexyl-vinyl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester | HCID 68583478 | — |
Reaction Steps
{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (137 mg, 0.25 mmol) was coupled with 2-cyclohexylvinylboronic acid (59 mg, 0.38 mmol) according to general procedure G to give {-4-[2-[4-(2-cyclohexyl-vinyl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404731B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5cd58687905942a290cc3198c5d83d9b |
| Source note | uspto-grants-2013_03 |