HuagongsheHuagongshe Chemistry Print Report · For research reference only
{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester → (4-{4-(2,4-Dichloro-phenyl)-2-[4'-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester | HCID 68583535 | — |
| Reactant | 4-(4-Methylpentyl)phenyl boronic acid | HCID 68583667 | — |
| Product | (4-{4-(2,4-Dichloro-phenyl)-2-[4'-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester | HCID 68583189 | — |
Reaction Steps
{-4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester (500 mg, 0.91 mmol) was coupled with 4-(4-methylpentyl)phenyl boronic acid according to general procedure G to give (4-{4-(2,4-dichloro-phenyl)-2-[4′-(4-methyl-pentyl)-biphenyl-4-ylmethyl]-imidazol-1-yl}-phenylamino)-acetic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404731B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-925dc5de9856452ea46a9625f1a0edb0 |
| Source note | uspto-grants-2013_03 |