反应详情

1 N hydrochloric acid/ethanol (105 ml, 105 mmol) and 5% palladium carbon (3 g) were added to an ethanol (250 ml) solution of the compound (15.5 g, 51 mmol) obtained in Step 4 above and the resulting mixture was subjected to catalytic reduction for 15 hours in a hydrogen atmosphere. The catalyst was removed by filtration through celite and then the filtrate was concentrated under reduced pressure. An ethanol/diethyl ether mixed solvent was added to the residue obtained and the deposited solid was collected by filtration to give the title compound (10.3 g, 83%) as a colorless solid.

1. customThe catalyst was removed by filtration through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionAn ethanol/diethyl ether mixed solvent was added to the residue
4. customobtained
5. filtrationthe deposited solid was collected by filtration