HCID 86642398, compound → HCID 86642397, compound

HRID 1951976Notes

Reaction equation

HRID 1951976 reaction equation
[CH2:1]([S:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][C:19]=2[O:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:11][C:10]=1[O:31][CH3:32])(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4]>ClCCl.[O-2].[Mn+2]>[CH2:1]([S:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH:24]=[O:25])=[CH:20][C:19]=2[O:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:11][C:10]=1[O:31][CH3:32])(=[O:6])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 86642398HCID 86642398, compound

Product 1

HCID 86642397HCID 86642397, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

7.9 g (91 mmol) of manganese oxide is added to a solution of 4.2 g (9.1 mmol) of 4-[3-(2-butoxy-4-hydroxymethyl-phenyl)-propyl]-2-methoxy-phenyl 1-butane sulfonate in 300 ml of dichloromethane. The reaction mixture is stirred for 15 hours at room temperature and then filtered on Celite. The solvents are evaporated. 3.9 g (94%) of 4-[3-(2-butoxy-4-formyl-phenyl)-propyl]-2-methoxy-phenyl 1-butane sulfonate is obtained in the form of a yellow oil.

Workup

  1. filtrationfiltered on Celite
  2. customThe solvents are evaporated

Sources & evidence

ORD record
ord-52cacdc7f0564f6fa9fb4ef7b165e431
Source dataset
uspto-grants-2013_03
Patent number
US08404836B2

Reaction notes

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