Water → HCID 68602836, compound

Participants

Reaction Steps

0.9 g (23 mmol) of 60% sodium hydride is added in portions to a previously cooled solution of 4 g (19 mmol) of (4-hydroxy-3-methoxy-phenyl)-ethyl acetate in 20 ml of tetrahydrofuran and 20 ml of dimethylformamide. After stirring at room temperature for 45 minutes, 2.4 ml (21 mmol) of 1-chloromethoxy-2-methoxy-ethane is added dropwise. After stirring at room temperature for 1 hour, water and ethyl acetate are added. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered, and evaporated. 5.5 g (97%) of [3-methoxy-4-(2-methoxy-ethoxymethoxy)-phenyl]-ethyl acetate is obtained.

Provenance & Evidence