Methanesulfonic Acid → HCID 68552740, compound

Participants

Reaction Conditions

Reaction Steps

2,2-dimethoxy propane (1050 ml) and 2.6 ml of methane sulfonic acid added to a solution of 280 grams of (3R,5S)-6-chloro-3,5-dihydroxy-N,N-diisopropylhexanamide, 1500 ml of acetone. Stirred the reaction mixture for 3 hours at 25-35° C. Quenched the reaction mixture with sodium bicarbonate solution. Separated the organic and inorganic phases. Extracted the aqueous layer with petroleum ether and washed the organic layer with brine solution. Dried the organic layer over sodium sulfate. Distilled the solvent completely under reduced pressure to get the title compound as a residue.

Provenance & Evidence