Potassium Bromide → HCID 24826226, compound

Participants

Reaction Steps

1 gram of potassium bromide and 0.1 gram of 2,2,6,6-tetramethyl-1-piperidinyloxy free radical is added to the a solution of 25 grams of 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-diisopropylacetamide in methylene chloride at 0-5° C. Added sodium hypochlorite to the above reaction mixture at 0-5° C. in 1 hour. Stirred the reaction for 30 minutes at 0-5° C. Quenched the reaction mixture with 10% sodium thio sulphate solution. Separated the organic and inorganic phases. Washed the organic layer with water. Dried the organic layer over sodium sulfate. Distilled the solvent completely under reduced pressure to get the title compound.

Provenance & Evidence