4-Chlorobenzylamine → HCID 15982217, compound

HRID 1952025Notes

Reaction equation

HRID 1952025 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[CH3:10][O:11][C:12]1[CH:20]=[CH:19][N:18]=[C:17]2[C:13]=1[CH:14]=[CH:15][NH:16]2.Cl[C:22]1[CH:30]=[CH:29][N:28]=[C:27]2[C:23]=1[CH:24]=CN2>>[CH3:10][O:11][C:12]1[CH:20]=[CH:19][N:18]=[C:17]2[NH:16][CH:15]=[C:14]([CH2:24][C:23]3[CH:22]=[CH:30][C:29]([NH:7][CH2:6][C:5]4[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=4)=[N:28][CH:27]=3)[C:13]=12

Participants

4

Reactant 3

HCID 660364-ChlorobenzylamineHCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridineHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 15982217HCID 15982217, compound

Procedure

was prepared following the protocol of Scheme 12, substituting 4-trifluoro-benzylamine with 4-chloro-benzylamine in Step 1 and 4-methoxy-7-azaindole with 4-chloro-7-azaindole (24, prepared as described in Example 11) in Step 4. MS (ESI) [M+H+]+=381.1 and 383.0.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-da94604340cf45578c6b926c88ab08e7
Source dataset
uspto-grants-2013_03
Patent number
US08404700B2

Reaction notes

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