HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde | HCID 5372812 | — |
Reaction Steps
To 1H-Pyrrolo[2,3-b]pyridine (1, 16.0 g, 135 mmol) in water (110 mL), were added hexamethylenetetramine (26.0 g, 185 mmol), and acetic acid (55.0 mL, 967 mmol). The reaction was refluxed for 12 hours. Water (329 mL) was added and the reaction was cooled to room temperature. The reaction was filtrated and washed with water to give compound (46, 15.0 g, 76%). MS (ESI)[M+H+]+=147.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404700B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-7d31031979124cce8af00f19966c767b |
| Source note | uspto-grants-2013_03 |