HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N,N-dimethyl-6-nitropyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N,N-dimethyl-6-nitropyridin-3-amine | HCID 21897368 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
6 ml of a 2M solution of dimethylamine in tetrahydrofuran are added to a solution of 1 g of 5-bromo-2-nitropyridine in 5 ml of ethanol. The reaction mixture is heated at 140° C. for 2 hours in a microwave device. After cooling, the solid formed is separated off and washed with ethyl ether to give 850 mg of N,N-dimethyl-6-nitropyridine-3-amine in the form of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404848B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-155dc77790ec4244a92a420f4f8671e7 |
| Source note | uspto-grants-2013_03 |