Hydrochloric Acid → HCID 59490928, compound

Participants

Reaction Conditions

Reaction Steps

Compound B4 was diluted with tetrahydrofuran (3 mL) and to the resulting solution was added 1M aqueous lithium hydroxide (2 mL, excess). The reaction was heated to 70° C. and allowed to stir at this temperature for 14 hours. The reaction was then acidified using 1M HCl, and extracted several times with ethyl acetate. The organic layer was collected and concentrated in vacuo to provide 1-(2-Fluoro-benzyl)-3-(2-methoxy-pyridin-3-yl)-5-methyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid B5 (0.2 g, 80% yield). MS: 392.16 (M+H)+.

Provenance & Evidence