HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1952230Generated: November 2, 2026
Hydrochloric Acid → 5-Bromo-6-fluoro-1H-indazole
https://huagongshe.com/reaction/1952230
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone | HCID 59694475 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Bromo-6-fluoro-1H-indazole | HCID 46863923 | — |
Reaction Steps
A solution of 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone (2C, 5.0 g, 19.5 mmol) was treated with aq HCl (3M soln., 100 mL) and methanol (20 mL) and heated at 90° C. for 3 h, when the reaction turns homogenous. The reaction mixture was cooled to room temperature and basified with aq. NaOH. A colorless solid precipitated out which was filtered and dried to yield 5-bromo-6-fluoro-1H-indazole (22D)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08404845B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-aba62a718dae462099a6d7752d719405 |
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| Source note | uspto-grants-2013_03 |
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