Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → Methyl 3-[4-(4-pyridinyl)-6-quinolinyl]-2-propenoate

Participants

Reaction Steps

A mixture of 4-(4-pyridinyl)-6-quinolinecarbaldehyde (2.29 g, 9.78 mmol), methyl (triphenylphosphoranylidene)acetate (3.30 g, 9.78 mmol) in MeOH (75 mL) was stirred at room temperature for 1 hour. The reaction was evaporated under reduced pressure and the resulting residue was purified by silica gel chromatography (1% MeOH in EtOAc) to give the title compound (2.71 g, 95%) as a white solid. MS(ES)+ m/e 291 [M+H]+.

Provenance & Evidence