HCID 59529771, compound → HCID 59529781, compound

Participants

Reaction Steps

Compound 2-4 (135 mg; 0.49 mmol) was hydrogenated in the presence of 10% Pd on carbon catalyst (25 mg) under 1 atmosphere hydrogen pressure (balloon) at room temperature. After 45 minutes LC-MS indicated that the reduction was complete. The reaction mixture was filtered through Celite, and the filtrate concentrated in vacuo to give the title product as a clear oil/solid. MS M+1=251. 1H NMR (CDCl3): 1.61 (m, 1H), 1.78 (m, 2H), 1.92 (dd, 1H), 2.03 (br m, 1H), 2.13 (br m, 1H), 2.60 (br m, 1H), 3.80 (br t, 1H), 4.12 (dd, 1H), 4.22 (br s, 2H), 5.93 (dd, 1H), 6.78 (dd, 1H), 8.21 (t, 1H).

Provenance & Evidence