HCID 59529757, compound → HCID 59529784, compound

Participants

Reaction Steps

Compound 4-1 (400 mg; 0.694 mmol) was dissolved in 6 mL THF/MeOH (1:1) and the system purged with nitrogen (3×). 10% Pd/C (739 mg; 0.694 mmol) was then added to the reaction mixture which was then purged (3×) with nitrogen and then with hydrogen (3×). The purged reaction mixture then remained under atmospheric pressure of hydrogen for 4 hours at room temperature. The reaction mixture was then filtered through celite and concentrated. The crude product was then purified by flash chromatography (40-100% EtOAc in hexane) to give the title compound. MS M+1: 577.6. 1H NMR (CDCl3): 2.12 (t, 2H), 3.32 (t, 2H), 3.76 (s, 3H), 3.90 (s, 3H), 5.53 (s, 2H), 6.30 (s, 1H), 6.65 (d, 1H), 6.68 (d, 2H), 7.08 (m, 1H), 7.12 (m, 1H), 7.20 (d, 2H), 7.42 (m, 1H), 7.94 (t, 1H).

Provenance & Evidence