Potassium Carbonate → HCID 68510351, compound

Participants

Reaction Conditions

Reaction Steps

3-Chloro-2,4,5,6-tetrafluoropyridine (10-1; 1.0 g; 5.39 mmol) and Compound 1-4 (0.83 g; 5.39 mmol) were dissolved in DMF and the solution cooled to −50° C. under a nitrogen atmosphere, after which potassium carbonate (1.12 g; 8.09 mmol) was added and the mixture allowed to slowly warm to 25° C. The reaction mixture was quenched with water and extracted with ethyl acetate. The organic extract was concentrated and purified on a silica column eluted with ethyl acetate:hexane to give the title product 10-2 as a clear oil. Rf=0.6 (EtOAc:hx, 5:95). 1H NMR (CDCl3): δ 7.50 (s, 1H), 7.24 (s, 1H), 7.17 (s, 1H).

Provenance & Evidence