HCID 12164460, compound → (2-Methoxyphenyl)(phenyl)phosphane

Participants

Reaction Conditions

Reaction Steps

To a well stirred suspension of lithiumaluminium hydride (266.0 mg, 7.0 mmol) in 50 mL of ether was added dropwise a solution of 2-methoxyphenyl-phenylchlorophosphine (3.20 g, 12.8 mmol) in 10 mL ether. Reaction was heated under reflux for 12 hrs and then allowed to cool to room temperature (ca. 20° C.). The excess of hydride was destroyed by the careful addition (dropwise) of 30 mL of water. Organic phase was separated and the aqueous phase was extracted with ether (2×60 mL). The organic layers were combined, dried over MgSO4 and concentrated to give 2.2 g (82%) of 2-methoxyphenyl-phenylphosphine.

Provenance & Evidence