Methanol → Methyl pyrrole-2-carboxylate

Participants

Reaction Steps

To a stirred solution of 2-(trichloroacetyl)pyrrole (10.00 g, 47.1 mmol) in MeOH (20 mL) was added K2CO3 (8.44 g, 61.2 mmol). The resulting mixture was stirred under reflux for 3 hours, cooled to room temperature and filtered. The filtrate was concentrated in vacuo to give 2 as a dark brown solid (5.50 g, 93%). 1H NMR (CDCl3) δ 9.49 (bs, 1H), 6.92-6.96 (m, 2H), 6.26 (m, 1H), and 3.86 (s, 3H); 13C NMR (CDCl3) δ 162.05, 123.33, 122.79, 115.56, 110.66, and 51.72.

Provenance & Evidence