Ethanol → HCID 86671252, compound

Participants

Reaction Steps

A mixture of ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate (0.28 g, 1.361 mmol), 3-(1H-Indazol-4-yl)-propylamine (300 mg, 1.712 mmol), potassium acetate (180 mg, 1.834 mmol) and ethanol (3 mL) was microwaved for 90 min. at 160° C. The reaction is diluted with ethyl acetate (150 mL) and water (30 mL). and washed with brine (2×30 mL), dried over anhydrous magnesium sulfate, filtered, concentrated to give 2-[3-(1H-Indazol-4-yl)-propylamino]-4-methyl-thiazole-5-carboxylic acid methyl ester (0.230 g, 49%)) as a yellow solid. MS m/e 331.4 (M+H+).

Provenance & Evidence