Formic Acid → Methyl 5-formyl-3-methylthiophene-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

A solution of 5-diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester (4.41 g, 17.1 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (40 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 30 min. The mixture was concentrated under reduced pressure to afford the desired product which was not further purified (3.2 g, 100% yield).

Provenance & Evidence