Lithium hydroxide, monohydrate → 5-[1-(3-Hydroxy-phenyl)-ethyl-carbamoyl]-3-methyl-thiophene-2-carboxylic acid

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Reaction Steps

A solution of 5-[1-(3-hydroxy-phenyl)-ethyl-carbamoyl]-3-methyl-thiophene-2-carboxylic acid methyl ester (121 mg, 0.38 mmol) in THF/water (3 ml/1 ml) was treated with LiOH.H2O (158 mg, 3.8 mmol) at rt overnight. The reaction mixture was quenched with 1N HCl and extracted with EtOAc. The layers were separated. The organic layer was washed with brine, then dried over Na2SO4 and concentrated under reduced pressure to afford the desired product (112 mg, 100% yield).

Provenance & Evidence