Triethylamine → HCID 68226934, compound

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Reaction Steps

To a solution of (S)-3-Amino-2-({5-[(1H-indol-4-ylmethyl)-carbamoyl]-3-trifluoromethyl-thiophene-2-carbonyl}-amino)-propionic acid methyl ester trifluoro-acetic acid salt (0.32 g, 0.49 mmol) in anhydrous DMF (10 mL) was added triethylamine (0.20 mL, 1.47 mmol), HBTU (0.28 g, 0.74 mmol), HOBT (0.079 g, 0.59 mmol), and 2-Thiophenecarboxylic acid (0.069 g, 0.54 mmol). The mixture was stirred at room temperature 2 h, treated with EtOAc (100 mL), washed with brine, dried over sodium sulfate, filtered and evaporated. The solid residue was purified by column (0-80% EtOAc in hexane) to give 0.172 g (61%) colorless oil product. MS m/e 579.0 (M+H+).

Provenance & Evidence