Hydrochloric Acid → 5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carboxylic acid

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A mixture of 5-[3-(tert-Butyl-dimethyl-silanyloxy)-benzylcarbamoyl]-3-phenyl-thiophene-2-carboxylic acid methyl ester (180 mg, 0.37 mmol), lithium hydroxide monohydrate (310, mg, 7.47 mmol), THF (4 mL) and water (2 mL) was stirred 15 h, acidified with 1N HCl and extracted with EtOAc (×3). The organic extracts were combined, washed with brine, dried over sodium sulfate, filtered and evaporated to give the title compound, 140 mg (100%). MS m/e 354.0 (M+H+).

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