Triethylamine → HCID 68226867, compound

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Reaction Steps

To a solution of (S)-3-Amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt (0.27 mmol) in anhydrous DMF (5 mL) was added triethylamine (0.1 mL, 0.81 mmol), HBTU (0.15 g, 0.40 mmol), HOBT (0.044 g, 0.32 mmol), and 2-Thiophenecarboxylic acid (0.038 g, 0.30 mmol). The mixture was stirred at room temperature 1.25 h, treated with EtOAc (50 mL), washed with brine, dried over sodium sulfate, filtered and evaporated. The solid residue was purified by column (50-80% EtOAc in hexane) to give 0.040 g (26%) colorless oil product. MS m/e 564.0 (M+H+).

Provenance & Evidence