反应详情

A mixture of 3-Chloro-5-methyl-thiophene-2-carboxylic acid methyl ester (4.4 g, 23.1 mmol), NBS (5.1 g, 28.85 mmol), and ACHN in CCl4 (40 ml) was refluxed in a pressure tube over the weekend. The reaction mixture was cooled and evaporated. The residue was purified by column (0-5% EtOAc in hexane) to give 3.8 g (61%) yellow solid product.

1. temperaturewas refluxed in a pressure tube over the weekend
2. temperatureThe reaction mixture was cooled
3. customevaporated
4. customThe residue was purified by column (0-5% EtOAc in hexane)