Triethylamine → HCID 68226476, compound

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Reaction Steps

To a solution of (S)-3-Amino-2-({3-chloro-5-[(1H-indazol-4-ylmethyl)-carbamoyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester trifluoro-acetic acid salt (0.19 mmol) in anhydrous DMF (5 mL) was added triethylamine (0.08 mL, 0.57 mmol), HBTU (0.108 g, 0.29 mmol), HOBt (0.031 g, 0.23 mmol), and 2-Thiophenecarboxylic acid (0.029 g, 0.23 mmol). The mixture was stirred at room temperature 2 h, treated with EtOAc (30 mL), washed with brine, dried over sodium sulfate, filtered and evaporated. The solid residue was purified by column (0-100% EtOAc in hexane) to give 0.0487 g (47%) colorless oil. MS m/e 545.9 (M+H+).

Provenance & Evidence