反应详情

6,6-Diethoxy-2-methyl-hex-4-yn-3-ol (3.18 g, 18.46 mmol) was dissolved in dichloromethane (100 ml) and treated with activated MnO2 (30 g) at rt for 15 h. The reaction mixture was filtered through a plug of celite and Na2SO4. The filtrated was concentrated under reduced pressure and purified by flash chromatography with 0-15% EtOAc in hexane to afford the desired product (1.32 g, 36% yield).

1. filtrationThe reaction mixture was filtered through a plug of celite and Na2SO4
2. concentrationThe filtrated was concentrated under reduced pressure
3. custompurified by flash chromatography with 0-15% EtOAc in hexane