反应详情

6,6-Diethoxy-hex-4-yn-3-ol (4.30 g, 23.1 mmol) was dissolved in dichloromethane (200 ml) and treated with activated MnO2 (50 g) at rt for 15 h. The reaction mixture was filtered through a plug of celite and Na2SO4. The filtrated was concentrated under reduced pressure and purified by flash chromatography with 0-20% EtOAc in hexane to afford the desired product (1.46 g, 34% yield).

1. filtrationThe reaction mixture was filtered through a plug of celite and Na2SO4
2. concentrationThe filtrated was concentrated under reduced pressure
3. custompurified by flash chromatography with 0-20% EtOAc in hexane