反应详情

A mixture of 3-Bromo-5-methyl-thiophene-2-carboxylic acid methyl ester (1.66 g, 7.06 mmol), NBS (1.63 g, 9.18 mmol), and Benzoyl peroxide (0.085 g, 0.35 mmol) in CCl4 (15 ml) was refluxed in a pressure tube 15 h. The reaction mixture was cooled and evaporated. The residue was purified by column (0-15% EtOAc in hexane) to give 0.99 g (45%) yellow oil product.

1. temperaturewas refluxed in a pressure tube 15 h
2. temperatureThe reaction mixture was cooled
3. customevaporated
4. customThe residue was purified by column (0-15% EtOAc in hexane)