Fumaric Acid → HCID 23298920, compound

HRID 1952684Notes

Reaction equation

HRID 1952684 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2([C:27]#N)[CH2:14][CH2:13][N:12]([CH:15]3[C:25]4=[C:26]5[C:21](=[CH:22][CH:23]=[CH:24]4)[CH:20]=[CH:19][CH:18]=[C:17]5[CH2:16]3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>C(OCC)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH:15]1([N:12]2[CH2:11][CH2:10][C:9]3([N:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=4)[C:32](=[O:33])[CH2:27]3)[CH2:14][CH2:13]2)[C:25]2=[C:26]3[C:21](=[CH:22][CH:23]=[CH:24]2)[CH:20]=[CH:19][CH:18]=[C:17]3[CH2:16]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 23298898HCID 23298898, compound

Product 1

HCID 23298920HCID 23298920, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Reaction of (RS)-4-(3-chloro-phenylamino)-1-(acenaphthen-1-yl)-piperidine-4-carbonitrile in accordance with the general method of example 1 and treatment of the base with fumaric acid in diethyl ether yielded the title compound, white solid, m.p. 214° C. and MS: m/e=403.4 (M+H+).

Sources & evidence

ORD record
ord-8b45f8589e98427389323857ec2e11f4
Source dataset
uspto-grants-2000_09
Patent number
US06113527

Reaction notes

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