HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanopyridine → 3-Pyridinecarboximidic acid, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanopyridine | HCID 79 | — |
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Pyridinecarboximidic acid, methyl ester | HCID 10329343 | — |
Reaction Steps
A solution of nicotinonitrile (11.35 g) and sodium methoxide (1.1 g) in methanol was allowed to stand at ambient temperature under nitrogen for 18 hours, then acetic acid (1.2 ml) was added, and the solvent was removed in vacuo. The residue was triturated with cyclohexane, undissolved solid was removed by filtration, and the solvent was removed in vacuo to leave methyl pyridine-3-carboximidate as an orange oil (10.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114334 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-4c206c5bd049428ca5840ce598c209d9 |
| Source note | uspto-grants-2000_09 |