Furan → HCID 23299778, compound

Participants

Reaction Conditions

Reaction Steps

22.5 ml of an about 1.6M solution of butyllithium are slowly added dropwise at -78° C. to a solution of 2.46 g of furan in 30 ml of tetrahydrofuran. The mixture is stirred at -78° C. for 20 min., then at -20° C. for 2 hrs. The solution is again cooled to -78° C. and treated slowly with a solution of 4.68 g of phthalazine in 36 ml of tetrahydrofuran. The mixture is stirred at -78° C. for 2 hrs., then poured on to about 500 ml of ice-water and extracted 4 times with 150 ml of ethyl acetate each time. The organic phases are dried, concentrated and the residue is chromatographed immediately on 120 g of silica gel; eluent: hexane/ethyl acetate 3:7. 4.08 g of dark, impure 1-furan-2-yl-1,2-dihydrophthalazine are isolated.

Provenance & Evidence